| Challenger Sophia Antipolis | 04/04 08:30 | 26 | [205] Matteo Donati v Enzo Couacaud [240] | 6-7,7-6,6-2 | |
| Challenger Sophia Antipolis | 04/02 11:25 | 25 | [116] Marco Trungelliti v Matteo Donati [205] | Retired | |
| Challenger Sophia Antipolis | 04/01 11:50 | 24 | [205] Matteo Donati v Kenny de Schepper [276] | 6-2,6-0 | |
| Challenger Marbella | 03/27 11:40 | 25 | [117] Thiago Monteiro v Matteo Donati [208] | 7-6,6-4 | |
| Challenger Marbella | 03/25 16:40 | 24 | [193] Jurij Rodionov v Matteo Donati [208] | 6-3,4-6,4-6 | |
| Challenger Santiago | 03/06 14:00 | 25 | [208] Matteo Donati v Tung-Lin Wu [363] | 3-6,4-6 | |
| ATP Sao Paulo | 02/23 15:30 | 64 | [388] Pedro Sakamoto v Matteo Donati [211] | 6-1,6-4 | |
| ATP Rio de Janeiro | 02/16 18:00 | 64 | [210] Matteo Donati v Rogerio Dutra Silva [138] | 2-6,6-3,1-6 | |
| ATP - Montpellier | 02/03 12:30 | 64 | [132] Ruben Bemelmans v Matteo Donati [207] | 7-6,6-3 | |
| Challenger Quimper | 01/28 18:20 | 24 | [207] Matteo Donati v Lucas Miedler [275] | 3-6,4-6 | |
| Australian Open | 01/09 04:05 | 44 | [199] Stefano Napolitano v Matteo Donati [205] | 6-4,7-6 | |
| Challenger Playford | 01/01 02:40 | 24 | [187] Ernesto Escobedo v Matteo Donati [203] | 7-6,7-6 | |
| Challenger Bratislava | 11/06 10:00 | 25 | [225] Matteo Donati v Lorenzo Sonego [106] | 3-6,2-6 | |
| Challenger Eckental | 10/31 10:00 | 25 | [226] Matteo Donati v Hubert Hurkacz [79] | 3-6,6-3,3-6 | |
| ATP Stockholm | 10/14 09:00 | 64 | [184] Matteo Donati v Jurgen Zopp [130] | 4-6,4-6 | |
| Challenger Biella | 09/20 11:05 | 26 | [180] Matteo Donati v Stefano Travaglia [150] | Retired | |
| Challenger Biella | 09/18 10:30 | 25 | [180] Matteo Donati v Oscar Jose Gutierrez [398] | 6-3,6-3 | |
| Challenger Szczecin | 09/11 08:00 | 25 | Matteo Donati v Zdeněk Kolář | Cancelled | |
| Challenger Sevilla | 09/05 11:50 | 26 | [351] Facundo Arguello v Matteo Donati [182] | Retired | |
| Challenger Sevilla | 09/04 16:30 | 25 | [182] Matteo Donati v Yannick Maden [125] | 6-4,6-3 | |
| Challenger Como | 09/02 11:30 | 28 | [182] Matteo Donati v Salvatore Caruso [218] | 6-7,6-7 | |
| Challenger Como | 08/31 12:40 | 27 | [182] Matteo Donati v Filippo Baldi [286] | 1-6,6-3,6-2 | |
| Challenger Como | 08/29 16:00 | 26 | [182] Matteo Donati v Federico Coria [353] | Retired | |
| Challenger Como | 08/28 09:10 | 25 | [150] Rogerio Dutra Silva v Matteo Donati [182] | 0-6,4-6 | |
| US Open | 08/21 22:30 | 44 | [183] Matteo Donati v Stefano Travaglia [141] | 3-6,2-6 | |
| ATP Gstaad Qual | 07/21 09:45 | 64 | Jakub Paul v Matteo Donati | 4-6,6-4,6-4 | |
| Challenger Scheveningen | 07/17 12:20 | 25 | [174] Matteo Donati v Antoine Hoang [223] | 4-6,3-6 | |
| Challenger Perugia | 07/12 11:00 | 26 | [200] Gianluigi Quinzi v Matteo Donati [176] | 6-4,6-4 | |
| Challenger Perugia | 07/11 09:00 | 25 | [382] Gonzalo Escobar v Matteo Donati [176] | 6-7,4-6 | |
| Wimbledon Qual | 06/25 10:00 | 44 | [171] Matteo Donati v Bernard Tomic [146] | 6-7,3-6 |