[4] Santos Laguna 1-1 Club América [2] 2018-11-12 00:00
Stadium: Estadio TSM Corona Round: 16
Referee: Jorge Isaac Rojas Castillo Home Manager: Salvador Reyes Away Manager: Miguel Herrera
Head to Head
| Mexiko - Liga MX | 2018/05/14 00:00 | Club América v Santos Laguna | D | 2-2 |
| Mexiko - Liga MX | 2018/05/11 00:30 | Santos Laguna v Club América | W | 4-1 |
| Mexiko - Liga MX | 2018/04/29 02:00 | Club América v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2017/11/20 00:30 | Santos Laguna v Club América | L | 0-1 |
| Evropa - Přátelská utkání | 2017/07/06 01:30 | Club América v Santos Laguna | L | 3-2 |
| Mexiko - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club América | W | 2-1 |
| Mexiko - Pohár | 2017/03/02 02:30 | Santos Laguna v Club América | W | 2-1 |
| Mexiko - Pohár | 2017/01/19 02:30 | Club América v Santos Laguna | L | 3-2 |
| Mexiko - Liga MX | 2016/10/30 02:00 | Club América v Santos Laguna | L | 3-1 |
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club América v Santos Laguna | L | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club América | D | 0-0 |
| Mexiko - Liga MX | 2016/02/06 23:00 | Club América v Santos Laguna | L | 2-0 |
| Mexiko - Liga MX | 2015/08/15 02:30 | Santos Laguna v Club América | L | 0-2 |
| Mexiko - Liga MX | 2015/03/14 23:00 | Club América v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2014/09/27 02:30 | Santos Laguna v Club América | L | 1-4 |
| Mexiko - Liga MX | 2014/05/04 02:00 | Santos Laguna v Club América | W | 3-1 |
| Mexiko - Liga MX | 2014/05/01 01:00 | Club América v Santos Laguna | L | 5-3 |