Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Nick Hill
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | L | 34-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | W | 17-20 |
| NCAAF | 2019/08/29 23:30 | SO Illinois v SE Missouri St | L | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | L | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri St v SO Illinois | W | 17-35 |