Stadium: Gibbs Stadium Round: 1
Home Manager: Josh Conklin Away Manager: George Quarles
| NCAAF | 2021/10/02 19:30 | Wofford v East Tennessee State | W | 21-27 |
| NCAAF | 2019/10/05 19:30 | Wofford v East Tennessee State | L | 35-17 |
| NCAAF | 2018/10/20 17:30 | Wofford v East Tennessee State | L | 30-17 |
| NCAAF | 2017/10/28 17:00 | East Tennessee State v Wofford | L | 24-31 |
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | L | 55-45 |
| NCAAF | 2022/10/15 20:00 | East Tennessee State v Mercer | L | 33-55 |
| NCAAF | 2022/10/08 17:30 | East Tennessee State v VMI | W | 44-21 |
| NCAAF | 2022/10/01 19:00 | Tennessee Chattanooga v East Tennessee State | L | 24-16 |
| NCAAF | 2022/09/24 16:00 | East Tennessee State v Robert Morris | W | 45-3 |
| NCAAF | 2022/09/17 23:30 | Furman v East Tennessee State | L | 27-14 |
| NCAAF | 2022/09/10 20:00 | East Tennessee State v The Citadel | L | 17-20 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | W | 44-7 |
| NCAAF | 2022/10/15 17:30 | The Citadel v Wofford | W | 16-31 |
| NCAAF | 2022/10/08 17:00 | Wofford v Samford | L | 14-28 |
| NCAAF | 2022/10/01 17:30 | Mercer v Wofford | L | 42-7 |
| NCAAF | 2022/09/24 22:00 | Wofford v Kennesaw State | L | 22-24 |
| NCAAF | 2022/09/17 15:00 | Wofford v Virginia Tech | L | 7-27 |
| NCAAF | 2022/09/10 22:00 | Elon v Wofford | L | 26-0 |
| NCAAF | 2022/09/03 22:00 | Wofford v Tennessee Chattanooga | L | 0-31 |
| NCAAF | 2021/11/20 17:00 | Wofford v Severní Karolína | L | 14-34 |