[5] South Florida 3-41 Louisville [99] 2022-09-24 16:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Jeff Scott
Head to Head
| NCAAF | 2012/10/20 12:00 | Louisville v South Florida | L | 27-25 |
| NCAAF | 2011/11/25 12:00 | South Florida v Louisville | L | 24-34 |
| NCAAF | 2010/11/13 12:00 | Louisville v South Florida | W | 21-24 |
| NCAAF | 2009/11/21 12:00 | South Florida v Louisville | W | 34-22 |
| NCAAF | 2008/10/25 12:00 | Louisville v South Florida | L | 24-20 |
| NCAAF | 2007/11/17 12:00 | South Florida v Louisville | W | 55-17 |
| NCAAF | 2006/11/18 12:00 | Louisville v South Florida | L | 31-8 |
| NCAAF | 2005/09/24 12:00 | South Florida v Louisville | W | 45-14 |
Home History
| NCAAF | 2022/09/17 23:30 | South Florida v Florida | L | 28-31 |
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | W | 20-42 |
| NCAAF | 2022/09/03 20:00 | BYU v South Florida | L | 50-21 |
| NCAAF | 2021/11/26 20:30 | South Florida v Central Florida | L | 13-17 |
| NCAAF | 2021/11/20 17:00 | South Florida v Tulane | L | 14-45 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | L | 45-28 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | L | 14-29 |
Away History
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAA Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |