[9] NY Islanders 3-5 BUF Sabres [5] 2022-04-23 16:30
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-6 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | W | 1-4 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
Home History
| NHL | 2022/04/21 23:30 | NY Rangers v NY Islanders | L | 6-3 |
| NHL | 2022/04/19 23:30 | FLA Panthers v NY Islanders | L | 3-2 |
| NHL | 2022/04/17 23:30 | NY Islanders v TOR Maple Leafs | L | 2-4 |
| NHL | 2022/04/15 23:00 | NY Islanders v MON Canadiens | W | 3-0 |
| NHL | 2022/04/14 23:00 | NY Islanders v PIT Penguins | L | 3-6 |
| NHL | 2022/04/12 23:30 | PIT Penguins v NY Islanders | W | 4-5 |
| NHL | 2022/04/10 00:00 | NY Islanders v STL Blues | L | 1-6 |
| NHL | 2022/04/08 23:00 | NY Islanders v CAR Hurricanes | W | 2-1 |
Away History
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |