[13] Chicago Fire 3-1 Inter Miami CF [9] 2022-09-11 00:00
Stadium: Soldier Field
Referee: Matthew Conger Home Manager: Ezra Hendrickson Away Manager: Phil Neville
Head to Head
| USA - MLS | 2022/02/26 23:00 | Inter Miami CF v Chicago Fire | D | 0-0 |
| USA - MLS | 2021/08/18 23:30 | Inter Miami CF v Chicago Fire | L | 3-2 |
| USA - MLS | 2021/05/22 22:00 | Chicago Fire v Inter Miami CF | W | 1-0 |
Home History
| USA - MLS | 2022/09/03 21:30 | Columbus Crew v Chicago Fire | D | 0-0 |
| USA - MLS | 2022/08/31 23:30 | New England Revolution v Chicago Fire | D | 0-0 |
| USA - MLS | 2022/08/28 00:00 | Chicago Fire v CF Montréal | L | 0-2 |
| USA - MLS | 2022/08/21 22:00 | Chicago Fire v New York City FC | L | 0-2 |
| USA - MLS | 2022/08/13 23:30 | Philadelphia Union v Chicago Fire | L | 4-1 |
| USA - MLS | 2022/08/06 23:00 | Charlotte FC v Chicago Fire | W | 2-3 |
| USA - MLS | 2022/07/30 21:00 | Chicago Fire v Atlanta United | D | 0-0 |
| USA - MLS | 2022/07/24 02:00 | Vancouver Whitecaps v Chicago Fire | W | 1-3 |
Away History
| USA - MLS | 2022/08/31 23:30 | Columbus Crew v Inter Miami CF | L | 1-0 |
| USA - MLS | 2022/08/27 23:00 | New York Red Bulls v Inter Miami CF | L | 3-1 |
| USA - MLS | 2022/08/21 00:00 | Inter Miami CF v Toronto FC | W | 2-1 |
| USA - MLS | 2022/08/14 00:00 | Inter Miami CF v New York City FC | W | 3-2 |
| USA - MLS | 2022/08/06 23:30 | CF Montréal v Inter Miami CF | D | 2-2 |
| USA - MLS | 2022/08/04 02:30 | San Jose Earthquakes v Inter Miami CF | W | 0-1 |
| USA - MLS | 2022/07/31 00:00 | Inter Miami CF v FC Cincinnati | D | 4-4 |
| USA - MLS | 2022/07/23 23:00 | New York City FC v Inter Miami CF | L | 2-0 |