Stadium: Hinkle Fieldhouse
Home Manager: LaVall Jordan Away Manager: Tom Izzo
| NCAAB | 2021/11/12 23:30 | Western Michigan v Michigan State | W | 46-90 |
| NCAAB | 2021/11/10 00:00 | Kansas v Michigan State | L | 87-74 |
| NCAAB | 2021/03/19 02:19 | UCLA v Michigan State | L | 86-80 |
| NCAAB | 2021/03/11 16:30 | Michigan State v Maryland | L | 57-68 |
| NCAAB | 2021/03/07 21:30 | Michigan v Michigan State | W | 64-70 |
| NCAAB | 2021/03/05 00:00 | Michigan State v Michigan | L | 50-69 |
| NCAAB | 2021/03/03 01:00 | Indiana v Michigan State | W | 58-64 |
| NCAAB | 2021/02/28 19:00 | Michigan State v Maryland | L | 55-73 |
| NCAAB | 2021/11/14 01:00 | Troy v Butler | W | 59-70 |
| NCAAB | 2021/11/12 23:30 | Central Arkansas v Butler | W | 53-85 |
| NCAAB | 2021/11/09 23:45 | IUPUI v Butler | W | 47-56 |
| NCAAB | 2021/03/11 23:00 | Butler v Creighton | L | 56-87 |
| NCAAB | 2021/03/10 23:00 | Butler v Xavier | W | 70-69 |
| NCAAB | 2021/03/06 22:00 | Butler v Creighton | L | 73-93 |
| NCAAB | 2021/02/28 17:00 | Villanova v Butler | W | 61-73 |
| NCAAB | 2021/02/25 00:00 | Seton Hall v Butler | W | 52-61 |