[17] River Plate 1-2 Colon [21] 2021-07-18 21:00
Stadium: Estadio Monumental Antonio Vespucio Liberti Round: 1
Referee: Dario Herrera Home Manager: Marcelo Gallardo Away Manager: Eduardo Dominguez
Head to Head
| Argentina - Copa de la Liga Profesional | 2021/04/12 00:00 | River Plate v Colon | W | 3-2 |
| Argentina - Superliga | 2019/10/30 00:20 | River Plate v Colon | W | 2-1 |
| Argentina - Superliga | 2018/10/20 00:15 | Colon v River Plate | L | 1-0 |
| Argentina - Superliga | 2018/05/08 00:15 | Colon v River Plate | D | 0-0 |
| Argentina - Superliga | 2017/06/25 23:00 | Colon v River Plate | D | 0-0 |
| Argentina - Liga Profesional | 2016/03/13 23:00 | Colon v River Plate | L | 4-1 |
| Argentina - Liga Profesional | 2015/07/25 20:15 | River Plate v Colon | W | 3-1 |
| Argentina - Pohár | 2014/08/20 23:30 | River Plate v Colon | W | 4-2 |
Home History
| Copa Libertadores - kvalifikace | 2021/07/15 00:30 | River Plate v Argentinos Jrs | D | 1-1 |
| Copa Libertadores | 2021/05/25 22:15 | River Plate v Fluminense | L | 1-3 |
| Copa Libertadores | 2021/05/20 00:00 | River Plate v Independiente Santa Fe | W | 2-1 |
| Argentina - Copa de la Liga Profesional | 2021/05/16 20:30 | Boca Juniors v River Plate | L | 5-3 |
| Copa Libertadores | 2021/05/13 00:00 | Junior v River Plate | D | 1-1 |
| Argentina - Copa de la Liga Profesional | 2021/05/09 17:30 | River Plate v CA Aldosivi | W | 4-1 |
| Copa Libertadores | 2021/05/07 00:00 | Independiente Santa Fe v River Plate | D | 0-0 |
| Argentina - Copa de la Liga Profesional | 2021/05/02 19:30 | Banfield v River Plate | L | 1-0 |
Away History
| Argentina - Copa de la Liga Profesional | 2021/06/04 22:00 | Colon v Racing Club | W | 3-0 |
| Argentina - Copa de la Liga Profesional | 2021/05/31 22:00 | CA Independiente v Colon | W | 0-2 |
| Argentina - Copa de la Liga Profesional | 2021/05/16 00:00 | Colon v CA Talleres de Córdoba | W | 6-4 |
| Argentina - Copa de la Liga Profesional | 2021/05/09 21:00 | Colon v Union Santa Fe | D | 1-1 |
| Argentina - Copa de la Liga Profesional | 2021/05/01 00:00 | Colon v Arsenal de Sarandi | W | 2-0 |
| Argentina - Copa de la Liga Profesional | 2021/04/25 18:45 | Racing Club v Colon | L | 2-1 |
| Argentina - Copa de la Liga Profesional | 2021/04/19 00:00 | Colon v Godoy Cruz | D | 2-2 |
| Argentina - Torneo Regional Amateur | 2021/04/14 19:13 | Union Santa Fe LSF v Colon | W | 0-1 |