Head to Head
| Chile - Pohár | 2021/07/01 19:30 | La Serena v Colo Colo | W | 1-3 |
| Chile - Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | W | 2-0 |
| Chile - Primera Division | 2020/12/08 21:30 | Colo Colo v La Serena | L | 0-2 |
| Chile - Primera Division | 2020/03/07 15:00 | La Serena v Colo Colo | W | 1-2 |
| Chile - Pohár | 2017/08/03 00:00 | Colo Colo v La Serena | W | 4-0 |
| Chile - Pohár | 2017/07/09 19:30 | La Serena v Colo Colo | L | 4-1 |
Home History
| Chile - Pohár | 2021/07/01 19:30 | La Serena v Colo Colo | W | 1-3 |
| Chile - Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | W | 2-0 |
| Chile - Primera Division | 2021/05/23 19:00 | Huachipato v Colo Colo | W | 0-2 |
| Chile - Primera Division | 2021/05/09 00:30 | Colo Colo v Palestino | L | 1-2 |
| Chile - Primera Division | 2021/05/01 22:00 | Nublense v Colo Colo | L | 5-1 |
| Chile - Primera Division | 2021/04/25 20:00 | Colo Colo v Universidad de Chile | W | 1-0 |
| Chile - Primera Division | 2021/04/18 19:00 | Everton de Vina v Colo Colo | W | 0-2 |
| Chile - Primera Division | 2021/04/12 00:00 | Colo Colo v O'Higgins | L | 1-2 |
Away History
| Chile - Pohár | 2021/07/01 19:30 | La Serena v Colo Colo | L | 1-3 |
| Chile - Pohár | 2021/06/27 19:00 | La Serena v AC Colina | W | 5-0 |
| Chile - Pohár | 2021/06/23 19:30 | AC Colina v La Serena | W | 1-2 |
| Chile - Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | L | 2-0 |
| Chile - Primera Division | 2021/05/29 19:00 | La Serena v Melipilla | W | 5-1 |
| Chile - Primera Division | 2021/05/22 15:00 | Cobresal v La Serena | L | 2-0 |
| Chile - Primera Division | 2021/05/08 19:30 | La Serena v Nublense | W | 1-0 |
| Chile - Primera Division | 2021/05/01 00:00 | Everton de Vina v La Serena | W | 0-4 |